When it comes to cardiovascular health, there's growing interest in combining various supplements to target arterial plaque. Let's examine the scientific evidence behind combining vitamin K2, D3, C, nattokinase, EDTA, lysine, and citrulline, and understand how they might work together.
The Synergistic Relationship
Vitamin K2 and D3: The Power Couple
Research has shown that vitamins K2 and D3 work synergistically. According to The Journal of Food and Nutrition Research, these vitamins collaborate to regulate calcium metabolism, ensuring calcium is directed to bones rather than arteries. This partnership is crucial for preventing arterial calcification.
Nattokinase: The Enzyme Powerhouse
Nattokinase, derived from fermented soybeans, has shown promising results in cardiovascular health. Biomarker Insights reports that nattokinase may help reduce the size of existing arterial plaques and potentially slow the progression of atherosclerosis.
L-Citrulline: The Vasodilator
L-citrulline plays a unique role by boosting nitric oxide production, which helps arteries relax and improves blood flow. This vasodilation effect could complement the action of other supplements in the combination.
Understanding the Mechanisms
The Multi-Targeted Approach
Calcium Management
- Vitamin K2 activates matrix Gla protein (MGP), which prevents calcium from depositing in arterial walls
- Vitamin D3 ensures proper calcium absorption and utilization
- Together, they form a calcium "traffic control" system
Plaque Reduction
- Nattokinase may help break down fibrin, a protein involved in blood clot formation
- Vitamin C acts as an antioxidant, potentially helping prevent oxidative damage that can contribute to plaque formation
Blood Flow Enhancement
- L-citrulline improves nitric oxide production
- Lysine may support collagen formation for arterial wall strength
- EDTA is thought to help chelate minerals that might contribute to arterial buildup
Safety Considerations and Effectiveness
Important Precautions
Drug Interactions
- Those on blood thinners should be especially careful with nattokinase
- Vitamin K2 can interact with anticoagulant medications
- Always consult healthcare providers before combining supplements
Dosage Considerations
- The effectiveness of this combination hasn't been studied as a single protocol
- Individual components have varying levels of research support
- Optimal dosages for combination therapy aren't established
Research Gaps
It's important to note that while individual components show promise, there's limited research on their combined effects. Most studies focus on individual supplements or simpler combinations.
Practical Implementation
Suggested Approach
Start Gradually
- Introduce supplements one at a time
- Monitor for individual reactions
- Allow time to assess effects
Regular Monitoring
- Work with healthcare providers
- Consider regular cardiovascular checkups
- Track markers of arterial health
The Bottom Line
Key Takeaways
- The combination shows theoretical promise based on individual mechanisms
- More research is needed on the complete combination
- Professional medical supervision is essential
- Results may vary significantly among individuals
Remember that supplements should complement, not replace, a heart-healthy lifestyle. Diet, exercise, stress management, and regular medical check-ups remain the cornerstone of cardiovascular health.
A Note of Caution
While this combination of supplements is intriguing, it's crucial to approach it with careful consideration. The interaction between multiple supplements can be complex, and what works well individually might not necessarily provide additional benefits when combined. Always consult with healthcare providers before starting any new supplement regimen, especially one involving multiple components.
Now ...
Check out what a 2 time Nobel Prize Recipient, Linus Pauling, says about cleaning the arteries of plaque with vitamin C and the amino acid lysine: here
Check out supplements vitamin K2, D3, C, nattokinase, EDTA, lysine, and citrulline on Amazon
